Changes of dermal thickness. In each group on Day 14 and the group treated with peanut oil and without agents on Day 28 the mean dermal thickness were significantly increased compared to on Day 0 (*, Fisher's LSD test, P < 0.05). Compared to Day 0, BLM-induced scleroderma in control mice progressed and persisted after the subcutaneous injection of bleomycin had finished. There were no significant differences among mean dermal thickness of mice treated with etretinate, peanut oil, and without agent for 14 days. On Day 28, mean dermal thickness of mice treated with etretinate decreased significantly compared to the control groups (*, P < 0.05) and the group treated with etretinate for 14 days (*, P < 0.05).