Table 1
Changes of histopathological findings.

  B→E
Day 14
B→P
Day 14
B→Non
Day 14
B→E
Day 28
B→P
Day 28
B→Non
Day 28
Changes of the epidermis
Fragmentations of the collagen bundles ↑↑
Amount of the collagen bundles ↑↑ ↑↑ ↑↑ ↑↑ ↑↑
Thickness of the collagen bundles ↑↑ ↑↑ ↑↑ ↑↑ ↑↑
Thickness of the subcutaneous tissue ↑↑
→: no changes ↑: slightly increased ↑↑: increased, compared to Day 0

Takaharu Ikeda, Toshio Ohtani and Fukumi Furukawa

Vitamin A Derivative Etretinate Improves Bleomycin-induced Scleroderma

Allergology International 2005; 54: 419-425.

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